Mr. Boris Jordan reports

CURALEAF FIRST TO SECURE REGISTRATION FOR STANDARDIZED CANNABIS PREPARATIONS IN SPAIN

The Spanish Agency of Medicines and Medical Devices (AEMPS) has formally approved the registration of two standardized cannabis preparations (THC-dominant and CBD-dominant) developed by Curaleaf Holdings Inc.'s Spanish manufacturing subsidiary. These registrations clear the regulatory pathway for the supply of preparations to hospital pharmacies, where they can be used in the production of magistral formulas pursuant to medical prescription. Based on the official registry numbering (CAN-1 and CAN-2), Curaleaf is the first company to register standardized cannabis preparations in Spain under the country's new regulatory framework, Royal Decree 903/2025.

Approved by Spain's Council of Ministers on Oct. 7, 2025, Royal Decree 903/2025 establishes Spain's regulatory framework for the medicinal use of standardized cannabis preparations, setting out the requirements for their production, quality standards and registration with AEMPS. It provides, for the first time, a clear national pathway for patients to access standardized cannabis preparations through the health care system. Curaleaf's registrations under this new framework mark one of the first steps in bringing that pathway to life.

The registrations build on Curaleaf's long-established presence in Spain, where the company operates an EU-GMP (European Union good manufacturing practice) certified manufacturing facility and R&D (research and development) laboratory in Alicante. In May, 2020, Curaleaf's EU-GMP laboratory, Medalchemy SL, secured the first-ever licence granted by AEMPS to process medicinal cannabis derivatives for commercial distribution, an early milestone that laid the foundation for today's achievement.

"Spain, a country of nearly 50 million people, has always been central to Curaleaf's vision for Europe, and this registration is a defining moment for us," said Boris Jordan, chief executive officer and chairman of Curaleaf. "We were the first company to be licensed here in 2020, and we believe we are the first to register under this new framework today. This achievement reflects the strength of our team, our sustained investment in science and our conviction that patients deserve access to standardized, high-quality cannabis medicines."

The standardized preparations are expected to become available to patients through hospital pharmacies in due course, in line with the requirements of the new framework. Curaleaf will continue to work alongside health care professionals and partners to support access as Spain's regulated system takes shape.

About Curaleaf Holdings Inc.

Curaleaf Holdings is a leading international provider of consumer products in cannabis with a mission to enhance lives by cultivating, sharing and celebrating the power of the plant. As a high-growth cannabis company known for quality, expertise and reliability, the company and its brands, including Curaleaf, Select, Grassroots, Find, Dark Heart and Anthem, provide industry-leading service, product selection, and accessibility across the medical and adult use markets. Curaleaf International is powered by a strong presence in all stages of the supply chain. Its unique distribution network throughout Europe, Canada, and Australasia brings together pioneering science and research with cutting-edge cultivation, extraction and production. Curaleaf is listed on the Toronto Stock Exchange under the symbol CURA and trades on the OTCQX market under the symbol CURLF.

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