Mr. Vito Sanzone reports

PROMINO NUTRITIONAL SCIENCES INC. BEGINS PRECLINICAL TRIAL TO DEMONSTRATE EFFECTIVENESS OF PROMINO PATENTED IP FOR RETENTION OF MUSCLE MASS IN CANCER PATIENTS UNDERGOING AGGRESSIVE CHEMOTHERAPY TREATMENT

Promino Nutritional Sciences Inc. has begun a preclinical trial to demonstrate the effectiveness of the Promino patented intellectual property for the retention of muscle mass in cancer patients undergoing aggressive chemotherapy treatment. The preclinical trial will be led by Dr. Patrick Gunning, who was appointed as special adviser to the company on May 8, 2024, to conduct this trial.

Results of the preclinical trial are expected in 10 weeks. If testing affirms the effectiveness of the patented IP in retaining muscle mass in chemotherapy patients, the company will likely develop a specialized formula specifically for marketing to the practitioner channel in North America.

"Promino's patented essential amino acid blend may have value beyond being the purest source of digestible protein, but a powerful tool for patients undergoing aggressive chemotherapy treatment," said Promino's chief executive officer, Vito Sanzone. "Chemotherapy can cause significant muscle wasting, further compromising the patient's much-needed strength, and Promino may provide these patients a helpful tool in their fight."

Furthermore, following the company's latest corporate update on June 3, 2024, Promino has achieved the following milestones:

• Retail and e-commerce partnership announcements with Vitacost, iHerb and Jean Coutu;
• Manufactured 65,000 units of Rejuvenate and Promino;
• Relaunched direct-to-consumer marketing in July, 2024;
• Reached an agreement with the licensor of the patented muscle health blend used in Rejuvenate Muscle Activator and Promino products on an exclusive international rights provision for the ready-to-drink market, and strengthened the current terms for the powdered supplement business;
• Became the official protein drink of Las Vegas Lights FC, owned by Promino brand ambassador Jose Bautista;
• Received results of a clinical trial demonstrating that, on a gram-to-gram basis, the company's proprietary patented essential amino acid blend was shown to be superior to whey protein isolate; specifically, a single 3.6-gram serving of Rejuvenate Muscle Activator is equivalent to 40 grams of whey protein in triggering muscle protein synthesis.

About Promino Nutritional Sciences Inc.

Promino is an innovative and research-driven Canadian nutraceutical company specializing in the development of patented and science-based products for the global consumer packaged goods market, with a portfolio focused specifically on muscle health. Promino's lead product, Rejuvenate, is a patented proprietary formulation that is clinically proven to assist in the building, rebuilding, restoration and rejuvenation of natural muscle mass. Promino also offers Promino, an elite performance supplement for both professional and amateur athletes to accelerate muscle recovery, build strength and speed recovery from injury. Promino was founded in 2015 and is located in Burlington, Ont.

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