Mr. Ron Nagar reports

TEMPRAMED PROVIDES POSITIVE RECAP ON 2025 AND STRATEGIC OUTLOOK FOR 2026

Tempramed Technologies Ltd. has provided a positive recap on the year as well as a strategic outlook for the year ahead in 2026.

As 2025 ends, the company reflects on a transformative year marked by significant commercial progress, strategic partnerships and continued execution against its mission to address one of the world's most pressing health care challenges -- ensuring the safety and efficacy of temperature-sensitive medications for millions of individuals using injectable medication globally.

"Two thousand twenty-five represented an important year of execution and validation for Tempramed. As the company moves into 2026, the focus remains on expanding access to its life-saving technology while continuing to innovate at the intersection of science, patient needs and global health care systems. I am proud of the team for the work they have done this year, and for years prior. We are transforming a major industry and next year will be even more exciting than this one," said Ron Nagar, chief executive officer of Tempramed.

Ilan Cohen, chairman of Tempramed, commented: "I am extremely happy with the progress Tempramed made in 2025, from operational efficiencies to distribution and partnership expansion, as well as completing a public listing. We are addressing a long-standing global health care problem that directly impacts patient safety and outcomes. The company's technology has the potential to redefine how temperature-sensitive medications are protected worldwide, creating meaningful value for patients, health care systems and shareholders alike. Two thousand twenty-six will be a strong year for the company as we continue to expand and unlock commercialization opportunities globally. We look forward to providing continuous updates to our investors and stakeholders."

2025 Highlights: strategic expansion and preparing for global commercialization

1. Expanded global commercial footprint

During 2025, Tempramed meaningfully expanded its commercial distribution network across multiple international markets:

• Entered into an exclusive distribution partnership with Guri AAO, a leading consumer and health care distributor in Israel;
• Entered into a commercial distribution agreement with a leading Turkish health care distributor, providing access to one of Europe's highest diabetes-prevalence markets;
• Expanded its presence across Western Europe through strategic partnerships in the Netherlands, Belgium and Luxembourg;
• Secured a strategic agreement with Maccabi Health Care Services, Israel's second-largest HMO serving more than 2.8 million members, representing a major milestone in health care system adoption.

These partnerships materially advance Tempramed's ability to scale globally through institutional health care channels.

2. Accelerating market adoption

Tempramed's patented VIVI product line, including the VIVI Cap and VIVI EPI, continued to gain traction across retail, pharmacy and health care channels. The products remain the only non-powered solution on the market proven to protect temperature-sensitive injectable medications from real-world heat and cold exposure -- without refrigeration, batteries or external power.

3. Scientific and clinical leadership

In 2025, Tempramed strengthened its scientific foundation with the appointment of Prof. Lutz Heinemann, a globally recognized leader in diabetes research and insulin pharmacology, to its scientific advisory board. His expertise further reinforces the company's leadership in insulin temperature-stability science and clinical credibility.

4. Intellectual property expansion

The company continued to build a robust global intellectual-property portfolio with the granting of an additional patent in South Korea, expanding protection for its core thermal-regulation technology and further strengthening competitive barriers to entry.

Tempramed launched is VIVI Cap Smart device, expanding its product portfolio adding a digital health offering. The new device is an advanced evolution of flagship VIVI Cap product and integrates digital health functionality with its established passive temperature-protection technology. This next-generation device unlocks significant pharma, health care provider and real-time data opportunity to track compliance, efficacy, side effects and other important information. It also adds subscription-based business model to product offering with the connected mobile application.

5. Global manufacturing expansion

In December, the company announced a new manufacturing facility in Florida, United States. The new facility increases output, reduces cost of goods sold (COGS) and enhances service for B2B (business-to-business) customers to address the forecasted increased demand for products.

6. Brand and community engagement

Tempramed continued to engage meaningfully with the global diabetes community, including support of advocacy initiatives such as Beyond Type 1, reinforcing the company's commitment to improving real-world outcomes for people living with chronic disease.

7. Access to strategic capital through public markets to accelerate growth

In November, 2025, Tempramed went public on the Canadian Securities Exchange under VIVI and on the Frankfurt Stock Exchange (FSE) under the ticker 9DY and raised, oversubscribed, $7.4-million to help accelerate growth and global expansion.

8. A life-saving solution for a global problem

Hundreds of millions of people worldwide rely on insulin and other important injectables every day to survive. Yet, these drugs are often highly temperature sensitive, and exposure to heat or cold outside tightly controlled ranges can significantly reduce its potency. This risk is particularly acute during daily transport, travel and routine use -- well beyond traditional cold-chain environments.

Tempramed's patented VIVI technology directly addresses this unmet need. The VIVI platform is the only solution currently available that reliably maintains these drugs within its safe temperature range in real-world conditions -- without power, refrigeration or user intervention. By safeguarding medication efficacy, Tempramed is helping to protect patient health, reduce costly medication waste and improve quality of life for medication-dependent individuals worldwide.

Looking ahead to 2026, Tempramed is focused on executing a disciplined growth strategy centered on scale, access and innovation:

• Global market expansion: accelerating penetration in valuable markets across North America, Europe, the Middle East and Asia through new health care, payor and pharmacy partnerships;
• Product innovation: advancing next-generation product development to expand the VIVI platform into additional medication categories and use cases;
• Health care system integration: deepening relationships with HMOs, insurers, pharmaceutical partners and clinical networks to support broader adoption as part of standard-of-care solutions. Working toward achieving insurance reimbursement for the product portfolio;
• Education and awareness: expanding clinical and patient education initiatives focused on the real-world impact of temperature exposure on efficacy of temperature sensitive medication.

About Tempramed Technologies Ltd.

Tempramed Technologies is a global leader in innovative, temperature-controlled medication storage solutions. Founded with the mission to safeguard the effectiveness of life-saving medications, Tempramed develops patented, Food and Drug Administration-registered, space-grade thermal insulation devices that work 24/seven without batteries or external power. With a proven product line including VIVI Cap and VIVI Epi, and a smart technology platform on the horizon, Tempramed enables patients and health care providers to confidently manage temperature-sensitive medications anywhere, anytime. Headquartered in Israel with operations in North America, Europe and Asia, Tempramed is advancing the future of medication protection and adherence.

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