Mr. Donald McCaffrey reports

RESVERLOGIX ANNOUNCES PUBLICATION OF ITS 40TH SCIENTIFIC JOURNAL ARTICLE ON APABETALONE'S POTENTIAL THERAPEUTIC BENEFITS

Resverlogix Corp. has learned that an article entitled "The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation," by Dr. Sylwia Wasiak and colleagues, has been published in Translational Neuroscience. This publication marks the 40th peer-reviewed scientific journal article published by Resverlogix researchers on apabetalone's potential therapeutic benefits.

Apabetalone's publication record

Articles on apabetalone have been published in some of the world's most prestigious scientific journals, including: Nature, Science, Cell, the Journal of the American Medical Association, Cardiovascular Diabetology and the Clinical Journal of the American Society of Nephrologists.

Resverlogix researchers and collaborators have published 40 articles on apabetalone in scientific journals, and including work by third party researchers, there are more than 100 articles on apabetalone in the academic literature.

This body of work presents evidence of apabetalone's potential in the treatment of cardiovascular disease, diabetes, post-COVID-19 conditions, chronic kidney disease and vascular cognitive impairment, as well as rare diseases such as pulmonary arterial hypertension, facioscapulohumeral muscular dystrophy and Fabry's disease.

The publications also cover a wide spectrum of topics from investigations of apabetalone's mechanism of action at a molecular level, to reports on large-scale clinical trials with thousands of participants.

"We are very proud of our publication record on apabetalone," said Dr. Ewelina Kulikowski, chief scientific officer at Resverlogix. "Thanks to the dedicated work of our researchers, we have learned an incredible amount about this drug; how it works, why it's safe, and how it can potentially benefit people suffering from chronic disease."

"The depth and breadth of our knowledge of apabetalone is on full display in the 40 scientific articles that we have published to date," said Donald McCaffrey, president and chief executive officer at Resverlogix. "We firmly believe that apabetalone will help chronic disease patients, we have published an extraordinary amount of evidence that supports our belief, and we are looking forward to conclusively demonstrating it in our upcoming phase 3 cardiovascular disease trial, BETonMACE2."

Highlights from the latest publication:

• Inflammation in the small blood vessels of the brain is linked to cognitive impairment and decline;

• Using cultured human brain endothelial cells and monocytes, the authors studied apabetalone's effects on inflammation in these small vessels;

• They found that apabetalone treatment reduced the production of pro-inflammatory molecules and cell-cell interactions;

• Their findings were confirmed in a mouse model of brain inflammation, where apabetalone decreased the expression of pro-inflammatory genes;

• By lessening inflammation in the small blood vessels of the brain, apabetalone may help prevent or treat vascular cognitive impairment.

About apabetalone

Apabetalone (RVX-208) is a first-in-class, small molecule, therapeutic candidate with an epigenetic mechanism of action. It is a BD2 (bromodomain) selective BET (bromodomain and extraterminal) inhibitor that works in preventing and treating disease by regulating the expression of disease-causing genes.

Due to the extensive role for BET proteins in the human body, apabetalone can simultaneously target multiple disease-related biological processes representing a new way to treat chronic disease. Apabetalone is the only drug of its class that is well tolerated for chronic administration, with an established safety record across multiple human clinical trials, totalling over 4,200 patient-years of safety data.

Cardiology

Apabetalone is the first therapy of its kind to receive breakthrough therapy designation from the U.S. Food and Drug Administration for a major cardiovascular indication. This followed the groundbreaking findings from its phase 3 study, BETonMACE, which showed apabetalone may prevent major adverse cardiac events among high-risk cardiovascular disease patients who also have Type 2 diabetes mellitus.

About Resverlogix Corp.

Founded in 2001, Resverlogix is a Calgary based late-stage biotechnology company and the world leader in epigenetics, with the goal of developing first-in-class therapies for the benefit of patients with chronic disease.

Resverlogix is developing a new class of epigenetic therapies designed to regulate the expression of disease-causing genes. It aims to improve patients' lives by restoring biological functions -- altered by serious illnesses such as cardiovascular disease -- back to a healthier state.

The company's clinical program is focused on evaluating the lead epigenetic candidate apabetalone for the treatment of cardiovascular disease, associated comorbidities and post-COVID-19 conditions.

Resverlogix has partnered with Eversana, the pioneer of next-generation commercial services to the global life sciences industry, to support the rapid commercialization of apabetalone for cardiovascular disease, post-COVID-19 conditions and pulmonary arterial hypertension in Canada and the United States.

We seek Safe Harbor.